Ed Oliver's ankle injury could tilt Week 2 in Buffalo's favor, forcing the Bills to lean on a thinner interior against a Jets rushing attack. New York aims to keep the game plan simple and punishing on the ground, with Fields carving running lanes behind a solid, cohesive line.

Four Jets stars must shine: Sauce Gardner shadows Buffalo's top options, Quinnen Williams thrives at three-tech, Bree Hall runs decisively, and Garrett Wilson remains the trusted target. Justin Fields' efficient Week 1 showing adds a layer of faith that the Jets can sustain a run-first approach while keeping passing efficient. Buffalo counterpunches with a receiver-by-committee approach led by Keon Coleman and Josh Allen spreading the ball around.

As Buffalo looks to prove it can stop the run, New York's formula hinges on simplicity on both sides of the ball and a disciplined run game that tests a potentially vulnerable defensive front. The matchup holds fantasy intrigue at every key position, especially for those betting on Jets-stacked concepts or Bills breakout targets in a still-developing offensive landscape.

Bills rally from a 15-point fourth-quarter hole to stun Baltimore 41-40 in a Week 1 classic, rewriting late-game fantasy appeal for Allen and company. Baltimore’s high-scoring pace is clear, but the win probability tilted Buffalo’s way late, with a backfield still mapping out roles and a defense that stretched for big plays.

In Minnesota, Jefferson endured drops but Addison flashed as a high-upside rookie, Pitts finally looked the part for Atlanta with big target counts, Flowers erupted for Baltimore, and Seattle’s JSN dominated targets. The opening slate sets up a wave of week-to-week pivots for fantasy managers.

Tyreek Hill’s off‑field situation dominates the slate as the NFL examines domestic allegations tied to Dolphins personnel. Miami has not shown immediate willingness to part with Hill, but the uncertainty drags his fantasy ceiling down in the short term even as his talent remains undeniable. Trade rumors will keep managers wary, with some evaluating quick sell‑high pivots while others hedge by targeting safer holds and savvy buys in Week 2.

On the field, London looks ready to return for Week 2 and Xavier Worthy’s absence tightens the door for Texans and other pass catchers, while Devonta Smith and Garrett Wilson sit squarely in the top tier of Week 2 lineups. James Cook hamstring updates, Brock Purdy backup risk, and Nico Collins health chatter all shape the waiver and trade landscape, alongside bold buy lows and strategic bench moves that could redefine fantasy value as Week 2 unfolds.

Week two centers the Travis Hunter debate for Liam Cohen and Jacksonville’s offense, weighing a rookie’s two-way usage against a looming road test at Cincinnati. The conversation pivots on whether Hunter will log more cornerback snaps or stay in the slot, with analysts cautioning that a heavy early NFL workload could blunt fantasy upside if kept to limited roles. Cincinnati’s offense, led by Joe Burrow and top targets Ja'Marr Chase and Tee Higgins, looms as a high-upside matchup, while Jacksonville contends with balancing speed, speed-adjustments, and the defense’s speed in coverage.

In Cleveland, rookie Dylan Samson and a slate of inexperienced Browns slot newcomers are scrutinized as potential fantasy plays behind an evolving offensive line, with Quinshon Judkins treated as a longer-term development rather than Week 2 bellcow. The discussion also touches Deion Dawkins and the Bills’ offense, noting his 89-snap performance and the toll it took, hinting at a possible easing of workload going forward. Overall, the episode threads thin threads of patience and pace for rookies and versatile players, urging managers to weigh workload against ceiling in Week 2.